The Canadian Consortium for the Investigation of Cannabinoids in Human Therapeutics
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Chen, R. Z., R. R. Huang, et al. (2004). "Synergistic effects of cannabinoid inverse agonist AM251 and opioid antagonist nalmefene on food intake in mice." Brain Res 999(2): 227-30. Oral administration of the opioid antagonist nalmefene alone (up to 20 mg/kg) failed to show a significant effect on acute food intake in mice. However, combined oral dosing of nalmefene and subthreshold doses of AM251, a cannabinoid CB1 receptor inverse agonist, led to a significant reduction in food intake in both lean and diet-induced obese (DIO) mice. Furthermore, the anorectic effect of a high dose of AM251 was further enhanced when coadministered with nalmefene. The results support a synergistic interaction between opioid and cannabinoid systems in regulating feeding behavior.
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The Canadian Consortium for the Investigation of Cannabinoids in Human Therapeutics
Here is the latest summary of research abstracts. A reminder that the 2005 Symposium on the Cannabinoids to be held June 24th 27th, 2005 at the Hilton Clearwater Beach Resort in Clearwater, Florida USA; registration details are available at http://CannabinoidSociety.org/. In addition a workshop entitled “Cannabinoids: developing clinically useful analgesics” has been announced at the Internatio...
متن کاملThe Canadian Consortium for the Investigation of Cannabinoids in Human Therapeutics
Ashton, J. C., I. Appleton, et al. (2004). "Immunohistochemical Localization of Cerebrovascular Cannabinoid CB1 Receptor Protein." J Cardiovasc Pharmacol 44(5): 517-9. Cannabinoids are powerful hypotensives and vasodilators. However, their mode of action is controversial. This study is the first to investigate the distribution of vascular CB1 receptor protein expression in situ. We used double-...
متن کاملThe Canadian Consortium for the Investigation of Cannabinoids in Human Therapeutics
Ashton, J. C., I. Appleton, et al. (2004). "Cannabinoid CB1 receptor protein expression in the rat choroid plexus: a possible involvement of cannabinoids in the regulation of cerebrospinal fluid." Neurosci Lett 364(1): 40-2. Cannabinoid CB1 receptors in the brain are expressed on axon terminals presynaptic to neurons that express fatty acid amide hydrolase (FAAH). Postsynaptic FAAH catabolizes ...
متن کاملThe Canadian Consortium for the Investigation of Cannabinoids in Human Therapeutics
Black, S. C. (2004). "Cannabinoid receptor antagonists and obesity." Curr Opin Investig Drugs 5(4): 389-94. The cannabinoid-1 (CB1) receptor plays a role in the regulation of appetitive behavior. Exogenously administered cannabinoid receptor agonists stimulate food consumption in animals and humans. Endogenous cannabinoid receptor agonists are present in the brain, and the brain level of these ...
متن کاملThe Canadian Consortium for the Investigation of Cannabinoids in Human Therapeutics
Ahmad, S. and A. Dray (2004). "Novel G protein-coupled receptors as pain targets." Curr Opin Investig Drugs 5(1): 67-70. G protein-coupled receptors (GPCRs) and their ligands play a number of important roles in the modulation of acute and chronic pain. Indeed, opioid and cannabinoid ligands are of established therapeutic value for pain management, and further exploitation of the specific GPCR s...
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